جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://192.168.1.35:80/jspui/handle/1842/706
Title: Developing a new paradigm for Thymus organogenesis
Authors: Blackburn, C Clare;Manley, Nancy R
Keywords: thymic epithelium
thymus
organogenesis
embryonic
origin
cortex
medulla
epithelium
Issue Date: 16-Feb-2005
Publisher: Nature Publishing Group
Description: The mature thymic epithelium is complex, with two major compartments — the cortex and the medulla — each containing several functionally distinct epithelial-cell types. There is considerable debate as to the embryonic origins of these different thymic epithelial-cell subpopulations. The textbook view is a dual origin, with cortical thymic epithelium arising from the ectoderm and medullary thymic epithelium originating in the endoderm. However, the literature has been divided on this issue since it was first considered. In this review, we discuss recent embryological, functional, genetic and molecular data that collectively support a new model of thymus organogenesis and patterning.
URI: http://192.168.1.35:80/jspui/handle/1842/706
Other Identifiers: Blackburn CC, Manley NR, NATURE REVIEWS IMMUNOLOGY, 4 (4): 278-289 APR 2004
doi:10.1038/nri1331
http://www.nature.com/
http://hdl.handle.net/1842/706
Type Of Material: Article
Appears in Collections:School of Biological Sciences

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