جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://192.168.1.35:80/jspui/handle/Hannan/10289
Title: New genetic loci link adipose and insulin biology to body fat distribution
Authors: Shungin, Dmitry;Winkler, Thomas W;Croteau-Chonka, Damien C;Ferreira, Teresa;Locke, Adam E;Mägi, Reedik;Strawbridge, Rona J;Pers, Tune H;Fischer, Krista;Justice, Anne E;Workalemahu, Tsegaselassie;Wu, Joseph M.W.;Buchkovich, Martin L;Heard-Costa, Nancy L;Roman, Tamara S;Drong, Alexander W;Song, Ci;Gustafsson, Stefan;Day, Felix R;Esko, Tonu;Fall, Tove;Kutalik, Zoltán;Luan, Jian’an;Randall, Joshua C;Scherag, André;Vedantam, Sailaja;Wood, Andrew R;Chen, Jin;Fehrmann, Rudolf;Karjalainen, Juha;Kahali, Bratati;Liu, Ching-Ti;Schmidt, Ellen M;Absher, Devin;Amin, Najaf;Anderson, Denise;Beekman, Marian;Bragg-Gresham, Jennifer L;Buyske, Steven;Demirkan, Ayse;Ehret, Georg B;Feitosa, Mary F;Goel, Anuj;Jackson, Anne U;Johnson, Toby;Kleber, Marcus E;Kristiansson, Kati;Mangino, Massimo;Leach, Irene Mateo;Medina-Gomez, Carolina;Palmer, Cameron D;Pasko, Dorota;Pechlivanis, Sonali;Peters, Marjolein J;Prokopenko, Inga;Stančáková, Alena;Sung, Yun Ju;Tanaka, Toshiko;Teumer, Alexander;Van Vliet-Ostaptchouk, Jana V;Yengo, Loïc;Zhang, Weihua;Albrecht, Eva;Ärnlöv, Johan;Arscott, Gillian M;Bandinelli, Stefania;Barrett, Amy;Bellis, Claire;Bennett, Amanda J;Berne, Christian;Blüher, Matthias;Böhringer, Stefan;Bonnet, Fabrice;Böttcher, Yvonne;Bruinenberg, Marcel;Carba, Delia B;Caspersen, Ida H;Clarke, Robert;Daw, E Warwick;Deelen, Joris;Deelman, Ewa;Delgado, Graciela;Doney, Alex SF;Eklund, Niina;Erdos, Michael R;Estrada, Karol;Eury, Elodie;Friedrich, Nele;Garcia, Melissa E;Giedraitis, Vilmantas;Gigante, Bruna;Go, Alan S;Golay, Alain;Grallert, Harald;Grammer, Tanja B;Gräßler, Jürgen;Grewal, Jagvir;Groves, Christopher J;Haller, Toomas;Hallmans, Goran;Hartman, Catharina A;Hassinen, Maija;Hayward, Caroline;Heikkilä, Kauko;Herzig, Karl-Heinz;Helmer, Quinta;Hillege, Hans L;Holmen, Oddgeir;Hunt, Steven C;Isaacs, Aaron;Ittermann, Till;James, Alan L;Johansson, Ingegerd;Juliusdottir, Thorhildur;Kalafati, Ioanna-Panagiota;Kinnunen, Leena;Koenig, Wolfgang;Kooner, Ishminder K;Kratzer, Wolfgang;Lamina, Claudia;Leander, Karin;Lee, Nanette R;Lichtner, Peter;Lind, Lars;Lindström, Jaana;Lobbens, Stéphane;Lorentzon, Mattias;Mach, François;Magnusson, Patrik KE;Mahajan, Anubha;McArdle, Wendy L;Menni, Cristina;Merger, Sigrun;Mihailov, Evelin;Milani, Lili;Mills, Rebecca;Moayyeri, Alireza;Monda, Keri L;Mooijaart, Simon P;Mühleisen, Thomas W;Mulas, Antonella;Müller, Gabriele;Müller-Nurasyid, Martina;Nagaraja, Ramaiah;Nalls, Michael A;Narisu, Narisu;Glorioso, Nicola;Nolte, Ilja M;Olden, Matthias;Rayner, Nigel W;Renstrom, Frida;Ried, Janina S;Robertson, Neil R;Rose, Lynda M;Sanna, Serena;Scharnagl, Hubert;Scholtens, Salome;Sennblad, Bengt;Seufferlein, Thomas;Sitlani, Colleen M;Smith, Albert Vernon;Stirrups, Kathleen;Stringham, Heather M;Sundström, Johan;Swertz, Morris A;Swift, Amy J;Syvänen, Ann-Christine;Tayo, Bamidele O;Thorand, Barbara;Thorleifsson, Gudmar;Tomaschitz, Andreas;Troffa, Chiara;van Oort, Floor VA;Verweij, Niek;Vonk, Judith M;Waite, Lindsay L;Wennauer, Roman;Wilsgaard, Tom;Wojczynski, Mary K;Wong, Andrew;Zhang, Qunyuan;Zhao, Jing Hua;Brennan, Eoin P.;Choi, Murim;Eriksson, Per;Folkersen, Lasse;Franco-Cereceda, Anders;Gharavi, Ali G;Hedman, Åsa K;Hivert, Marie-France;Huang, Jinyan;Kanoni, Stavroula;Karpe, Fredrik;Keildson, Sarah;Kiryluk, Krzysztof;Liang, Liming;Lifton, Richard P;Ma, Baoshan;McKnight, Amy J;McPherson, Ruth;Metspalu, Andres;Min, Josine L;Moffatt, Miriam F;Montgomery, Grant W;Murabito, Joanne M;Nicholson, George;Nyholt, Dale R;Olsson, Christian;Perry, John RB;Reinmaa, Eva;Salem, Rany M;Sandholm, Niina;Schadt, Eric E;Scott, Robert A;Stolk, Lisette;Vallejo, Edgar E.;Westra, Harm-Jan;Zondervan, Krina T;Amouyel, Philippe;Arveiler, Dominique;Bakker, Stephan JL;Beilby, John;Bergman, Richard N;Blangero, John;Brown, Morris J;Burnier, Michel;Campbell, Harry;Chakravarti, Aravinda;Chines, Peter S;Claudi-Boehm, Simone;Collins, Francis S;Crawford, Dana C;Danesh, John;de Faire, Ulf;de Geus, Eco JC;Dörr, Marcus;Erbel, Raimund;Eriksson, Johan G;Farrall, Martin;Ferrannini, Ele;Ferrières, Jean;Forouhi, Nita G;Forrester, Terrence;Franco, Oscar H;Gansevoort, Ron T;Gieger, Christian;Gudnason, Vilmundur;Haiman, Christopher A;Harris, Tamara B;Hattersley, Andrew T;Heliövaara, Markku;Hicks, Andrew A;Hingorani, Aroon D;Hoffmann, Wolfgang;Hofman, Albert;Homuth, Georg;Humphries, Steve E;Hyppönen, Elina;Illig, Thomas;Jarvelin, Marjo-Riitta;Johansen, Berit;Jousilahti, Pekka;Jula, Antti M;Kaprio, Jaakko;Kee, Frank;Keinanen-Kiukaanniemi, Sirkka M;Kooner, Jaspal S;Kooperberg, Charles;Kovacs, Peter;Kraja, Aldi T;Kumari, Meena;Kuulasmaa, Kari;Kuusisto, Johanna;Lakka, Timo A;Langenberg, Claudia;Le Marchand, Loic;Lehtimäki, Terho;Lyssenko, Valeriya;Männistö, Satu;Marette, André;Matise, Tara C;McKenzie, Colin A;McKnight, Barbara;Musk, Arthur W;Möhlenkamp, Stefan;Morris, Andrew D;Nelis, Mari;Ohlsson, Claes;Oldehinkel, Albertine J;Ong, Ken K;Palmer, Lyle J;Penninx, Brenda W;Peters, Annette;Pramstaller, Peter P;Raitakari, Olli T;Rankinen, Tuomo;Rao, DC;Rice, Treva K;Ridker, Paul M;Ritchie, Marylyn D.;Rudan, Igor;Salomaa, Veikko;Samani, Nilesh J;Saramies, Jouko;Sarzynski, Mark A;Schwarz, Peter EH;Shuldiner, Alan R;Staessen, Jan A;Steinthorsdottir, Valgerdur;Stolk, Ronald P;Strauch, Konstantin;Tönjes, Anke;Tremblay, Angelo;Tremoli, Elena;Vohl, Marie-Claude;Völker, Uwe;Vollenweider, Peter;Wilson, James F;Witteman, Jacqueline C;Adair, Linda S;Bochud, Murielle;Boehm, Bernhard O;Bornstein, Stefan R;Bouchard, Claude;Cauchi, Stéphane;Caulfield, Mark J;Chambers, John C;Chasman, Daniel I;Cooper, Richard S;Dedoussis, George;Ferrucci, Luigi;Froguel, Philippe;Grabe, Hans-Jörgen;Hamsten, Anders;Hui, Jennie;Hveem, Kristian;Jöckel, Karl-Heinz;Kivimaki, Mika;Kuh, Diana;Laakso, Markku;Liu, Yongmei;März, Winfried;Munroe, Patricia B;Njølstad, Inger;Oostra, Ben A;Palmer, Colin NA;Pedersen, Nancy L;Perola, Markus;Pérusse, Louis;Peters, Ulrike;Power, Chris;Quertermous, Thomas;Rauramaa, Rainer;Rivadeneira, Fernando;Saaristo, Timo E;Saleheen, Danish;Sinisalo, Juha;Slagboom, P Eline;Snieder, Harold;Spector, Tim D;Stefansson, Kari;Stumvoll, Michael;Tuomilehto, Jaakko;Uitterlinden, André G;Uusitupa, Matti;van der Harst, Pim;Veronesi, Giovanni;Walker, Mark;Wareham, Nicholas J;Watkins, Hugh;Wichmann, H-Erich;Abecasis, Goncalo R;Assimes, Themistocles L;Berndt, Sonja I;Boehnke, Michael;Borecki, Ingrid B;Deloukas, Panos;Franke, Lude;Frayling, Timothy M;Groop, Leif C;Hunter, David J.;Kaplan, Robert C;O’Connell, Jeffrey R;Qi, Lu;Schlessinger, David;Strachan, David P;Thorsteinsdottir, Unnur;van Duijn, Cornelia M;Willer, Cristen J;Visscher, Peter M;Yang, Jian;Hirschhorn, Joel N;Zillikens, M Carola;McCarthy, Mark I;Speliotes, Elizabeth K;North, Kari E;Fox, Caroline S;Barroso, Inês;Franks, Paul W;Ingelsson, Erik;Heid, Iris M;Loos, Ruth JF;Cupples, L Adrienne;Morris, Andrew P;Lindgren, Cecilia M;Mohlke, Karen L
Issue Date: 2014
Description: Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, we conducted genome-wide association meta-analyses of waist and hip circumference-related traits in up to 224,459 individuals. We identified 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and an additional 19 loci newly associated with related waist and hip circumference measures (P<5×10−8). Twenty of the 49 WHRadjBMI loci showed significant sexual dimorphism, 19 of which displayed a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation, and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
URI: http://192.168.1.35:80/jspui/handle/Hannan/10289
Other Identifiers: Shungin, D., T. W. Winkler, D. C. Croteau-Chonka, T. Ferreira, A. E. Locke, R. Mägi, R. J. Strawbridge, et al. 2014. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518 (7538): 187-196. doi:10.1038/nature14132. http://dx.doi.org/10.1038/nature14132.
0028-0836
http://nrs.harvard.edu/urn-3:HUL.InstRepos:21459269
Type Of Material: Journal Article
Appears in Collections:Harvard Medical School

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