جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://192.168.1.35:80/jspui/handle/Hannan/1583
Title: Chronic Lung Function Decline in Cotton Textile Workers: Roles of Historical and Recent Exposures to Endotoxin
Authors: Mehta, Amar J.;Hang, Jing-qing;Zhang, Hongxi;Dai, Helian;Shi, Ping;Su, Li;Eisen, Ellen A.;Christiani, David C.
Keywords: byssinosis
China
chronic obstructive lung disease
cotton textile workers
occupational health
organic dusts
pulmonary function
Issue Date: 2010
Publisher: National Institute of Environmental Health Sciences
Description: Background: Long-term occupational exposure to cotton dust that contains endotoxin is associated with chronic respiratory symptoms and excessive decline in forced expiratory volume in 1 sec (FEV1), but the mechanisms of endotoxin-related chronic airflow obstruction remain unclear. Objective: In the current study, we examined temporal aspects of the exposure–response relationship between airborne endotoxin exposure, longitudinal change in FEV1, and respiratory symptoms in a cohort of Chinese cotton textile workers. Methods: This prospective cohort study followed 447 cotton textile workers from 1981 to 2006.at approximately 5-year intervals. We used a generalized estimating equations approach to model FEV1 level and respiratory symptoms as a function of past exposure (cumulative exposure up to the start of the most recent 5-year survey interval) and cumulative exposure (within the most recent interval) to endotoxins, after adjusting for other covariates. Models were stratified by active versus retired work status and by years employed before the baseline survey (< 5 and ≥ 5 years). Results and conclusions: Past exposure to endotoxin was associated with reduced FEV1 level among retired cotton workers. Among all cotton workers, past exposure was more strongly associated with reduced FEV1 for those hired < 5 years before baseline than for those who were hired ≥ 5 years after baseline. Recent endotoxin exposure was significantly associated with byssinosis, chronic bronchitis, and chronic cough.
URI: http://192.168.1.35:80/jspui/handle/Hannan/1583
Other Identifiers: Shi, Jing, Amar J. Mehta, Jing-qing Hang, Hongxi Zhang, Helian Dai, Li Su, Ellen A. Eisen, and David C. Christiani. 2010. Chronic Lung Function Decline in Cotton Textile Workers: Roles of Historical and Recent Exposures to Endotoxin. Environmental Health Perspectives 118(11): 1620-1624.
0091-6765
http://nrs.harvard.edu/urn-3:HUL.InstRepos:4874478
Type Of Material: Journal Article
Appears in Collections:Harvard Medical School

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