جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://192.168.1.35:80/jspui/handle/Hannan/18131
Title: Defining the role of common variation in the genomic and biological architecture of adult human height
Authors: Wood, Andrew R;Esko, Tonu;Yang, Jian;Vedantam, Sailaja;Pers, Tune H;Gustafsson, Stefan;Chu, Audrey Y;Estrada, Karol;Luan, Jian’an;Kutalik, Zoltán;Amin, Najaf;Buchkovich, Martin L;Croteau-Chonka, Damien C;Day, Felix R;Duan, Yanan;Fall, Tove;Fehrmann, Rudolf;Ferreira, Teresa;Jackson, Anne U;Karjalainen, Juha;Lo, Ken Sin;Locke, Adam E;Mägi, Reedik;Mihailov, Evelin;Porcu, Eleonora;Randall, Joshua C;Scherag, André;Vinkhuyzen, Anna AE;Westra, Harm-Jan;Winkler, Thomas W;Workalemahu, Tsegaselassie;Zhao, Jing Hua;Absher, Devin;Albrecht, Eva;Anderson, Denise;Baron, Jeffrey;Beekman, Marian;Demirkan, Ayse;Ehret, Georg B;Feenstra, Bjarke;Feitosa, Mary F;Fischer, Krista;Fraser, Ross M;Goel, Anuj;Gong, Jian;Justice, Anne E;Kanoni, Stavroula;Kleber, Marcus E;Kristiansson, Kati;Lim, Unhee;Lotay, Vaneet;Lui, Julian C;Mangino, Massimo;Leach, Irene Mateo;Medina-Gomez, Carolina;Nalls, Michael A;Nyholt, Dale R;Palmer, Cameron D;Pasko, Dorota;Pechlivanis, Sonali;Prokopenko, Inga;Ried, Janina S;Ripke, Stephan;Shungin, Dmitry;Stancáková, Alena;Strawbridge, Rona J;Sung, Yun Ju;Tanaka, Toshiko;Teumer, Alexander;Trompet, Stella;van der Laan, Sander W;van Setten, Jessica;Van Vliet-Ostaptchouk, Jana V;Wang, Zhaoming;Yengo, Loïc;Zhang, Weihua;Afzal, Uzma;Ärnlöv, Johan;Arscott, Gillian M;Bandinelli, Stefania;Barrett, Amy;Bellis, Claire;Bennett, Amanda J;Berne, Christian;Blüher, Matthias;Bolton, Jennifer L;Böttcher, Yvonne;Boyd, Heather A;Bruinenberg, Marcel;Buckley, Brendan M;Buyske, Steven;Caspersen, Ida H;Chines, Peter S;Clarke, Robert;Claudi-Boehm, Simone;Cooper, Matthew;Daw, E Warwick;De Jong, Pim A;Deelen, Joris;Delgado, Graciela;Denny, Josh C;Dhonukshe-Rutten, Rosalie;Dimitriou, Maria;Doney, Alex SF;Dörr, Marcus;Eklund, Niina;Eury, Elodie;Folkersen, Lasse;Garcia, Melissa E;Geller, Frank;Giedraitis, Vilmantas;Go, Alan S;Grallert, Harald;Grammer, Tanja B;Gräßler, Jürgen;Grönberg, Henrik;de Groot, Lisette C.P.G.M.;Groves, Christopher J;Haessler, Jeffrey;Hall, Per;Haller, Toomas;Hallmans, Goran;Hannemann, Anke;Hartman, Catharina A;Hassinen, Maija;Hayward, Caroline;Heard-Costa, Nancy L;Helmer, Quinta;Hemani, Gibran;Henders, Anjali K;Hillege, Hans L;Hlatky, Mark A;Hoffmann, Wolfgang;Hoffmann, Per;Holmen, Oddgeir;Houwing-Duistermaat, Jeanine J;Illig, Thomas;Isaacs, Aaron;James, Alan L;Jeff, Janina;Johansen, Berit;Johansson, Åsa;Jolley, Jennifer;Juliusdottir, Thorhildur;Junttila, Juhani;Kho, Abel N;Kinnunen, Leena;Klopp, Norman;Kocher, Thomas;Kratzer, Wolfgang;Lichtner, Peter;Lind, Lars;Lindström, Jaana;Lobbens, Stéphane;Lorentzon, Mattias;Lu, Yingchang;Lyssenko, Valeriya;Magnusson, Patrik KE;Mahajan, Anubha;Maillard, Marc;McArdle, Wendy L;McKenzie, Colin A;McLachlan, Stela;McLaren, Paul J;Menni, Cristina;Merger, Sigrun;Milani, Lili;Moayyeri, Alireza;Monda, Keri L;Morken, Mario A;Müller, Gabriele;Müller-Nurasyid, Martina;Musk, Arthur W;Narisu, Narisu;Nauck, Matthias;Nolte, Ilja M;Nöthen, Markus M;Oozageer, Laticia;Pilz, Stefan;Rayner, Nigel W;Renstrom, Frida;Robertson, Neil R;Rose, Lynda M;Roussel, Ronan;Sanna, Serena;Scharnagl, Hubert;Scholtens, Salome;Schumacher, Fredrick R;Schunkert, Heribert;Scott, Robert A;Sehmi, Joban;Seufferlein, Thomas;Shi, Jianxin;Silventoinen, Karri;Smit, Johannes H;Smith, Albert Vernon;Smolonska, Joanna;Stanton, Alice V;Stirrups, Kathleen;Stott, David J;Stringham, Heather M;Sundström, Johan;Swertz, Morris A;Syvänen, Ann-Christine;Tayo, Bamidele O;Thorleifsson, Gudmar;Tyrer, Jonathan P;van Dijk, Suzanne;van Schoor, Natasja M;van der Velde, Nathalie;van Heemst, Diana;van Oort, Floor VA;Vermeulen, Sita H;Verweij, Niek;Vonk, Judith M;Waite, Lindsay L;Waldenberger, Melanie;Wennauer, Roman;Wilkens, Lynne R;Willenborg, Christina;Wilsgaard, Tom;Wojczynski, Mary K;Wong, Andrew;Wright, Alan F;Zhang, Qunyuan;Arveiler, Dominique;Bakker, Stephan JL;Beilby, John;Bergman, Richard N;Bergmann, Sven;Biffar, Reiner;Blangero, John;Boomsma, Dorret I;Bornstein, Stefan R;Bovet, Pascal;Brambilla, Paolo;Brown, Morris J;Campbell, Harry;Caulfield, Mark J;Chakravarti, Aravinda;Collins, Rory;Collins, Francis S;Crawford, Dana C;Cupples, L Adrienne;Danesh, John;de Faire, Ulf;den Ruijter, Hester M;Erbel, Raimund;Erdmann, Jeanette;Eriksson, Johan G;Farrall, Martin;Ferrannini, Ele;Ferrières, Jean;Ford, Ian;Forouhi, Nita G;Forrester, Terrence;Gansevoort, Ron T;Gejman, Pablo V;Gieger, Christian;Golay, Alain;Gottesman, Omri;Gudnason, Vilmundur;Gyllensten, Ulf;Haas, David W;Hall, Alistair S;Harris, Tamara B;Hattersley, Andrew T;Heath, Andrew C;Hengstenberg, Christian;Hicks, Andrew A;Hindorff, Lucia A;Hingorani, Aroon D;Hofman, Albert;Hovingh, G Kees;Humphries, Steve E;Hunt, Steven C;Hypponen, Elina;Jacobs, Kevin B;Jarvelin, Marjo-Riitta;Jousilahti, Pekka;Jula, Antti M;Kaprio, Jaakko;Kastelein, John JP;Kayser, Manfred;Kee, Frank;Keinanen-Kiukaanniemi, Sirkka M;Kiemeney, Lambertus A;Kooner, Jaspal S;Kooperberg, Charles;Koskinen, Seppo;Kovacs, Peter;Kraja, Aldi T;Kumari, Meena;Kuusisto, Johanna;Lakka, Timo A;Langenberg, Claudia;Le Marchand, Loic;Lehtimäki, Terho;Lupoli, Sara;Madden, Pamela AF;Männistö, Satu;Manunta, Paolo;Marette, André;Matise, Tara C;McKnight, Barbara;Meitinger, Thomas;Moll, Frans L;Montgomery, Grant W;Morris, Andrew D;Morris, Andrew P;Murray, Jeffrey C;Nelis, Mari;Ohlsson, Claes;Oldehinkel, Albertine J;Ong, Ken K;Ouwehand, Willem H;Pasterkamp, Gerard;Peters, Annette;Pramstaller, Peter P;Price, Jackie F;Qi, Lu;Raitakari, Olli T;Rankinen, Tuomo;Rao, DC;Rice, Treva K;Ritchie, Marylyn;Rudan, Igor;Salomaa, Veikko;Samani, Nilesh J;Saramies, Jouko;Sarzynski, Mark A;Schwarz, Peter EH;Sebert, Sylvain;Sever, Peter;Shuldiner, Alan R;Sinisalo, Juha;Steinthorsdottir, Valgerdur;Stolk, Ronald P;Tardif, Jean-Claude;Tönjes, Anke;Tremblay, Angelo;Tremoli, Elena;Virtamo, Jarmo;Vohl, Marie-Claude;Amouyel, Philippe;Asselbergs, Folkert W;Assimes, Themistocles L;Bochud, Murielle;Boehm, Bernhard O;Boerwinkle, Eric;Bottinger, Erwin P;Bouchard, Claude;Cauchi, Stéphane;Chambers, John C;Chanock, Stephen J;Cooper, Richard S;de Bakker, Paul IW;Dedoussis, George;Ferrucci, Luigi;Franks, Paul W;Froguel, Philippe;Groop, Leif C;Haiman, Christopher A;Hamsten, Anders;Hayes, M Geoffrey;Hui, Jennie;Hunter, David J.;Hveem, Kristian;Jukema, J Wouter;Kaplan, Robert C;Kivimaki, Mika;Kuh, Diana;Laakso, Markku;Liu, Yongmei;Martin, Nicholas G;März, Winfried;Melbye, Mads;Moebus, Susanne;Munroe, Patricia B;Njølstad, Inger;Oostra, Ben A;Palmer, Colin NA;Pedersen, Nancy L;Perola, Markus;Pérusse, Louis;Peters, Ulrike;Powell, Joseph E;Power, Chris;Quertermous, Thomas;Rauramaa, Rainer;Reinmaa, Eva;Ridker, Paul M;Rivadeneira, Fernando;Rotter, Jerome I;Saaristo, Timo E;Saleheen, Danish;Schlessinger, David;Slagboom, P Eline;Snieder, Harold;Spector, Tim D;Strauch, Konstantin;Stumvoll, Michael;Tuomilehto, Jaakko;Uusitupa, Matti;van der Harst, Pim;Völzke, Henry;Walker, Mark;Wareham, Nicholas J;Watkins, Hugh;Wichmann, H-Erich;Wilson, James F;Zanen, Pieter;Deloukas, Panos;Heid, Iris M;Lindgren, Cecilia M;Mohlke, Karen L;Speliotes, Elizabeth K;Thorsteinsdottir, Unnur;Barroso, Inês;Fox, Caroline S;North, Kari E;Strachan, David P;Beckmann, Jacques S.;Berndt, Sonja I;Boehnke, Michael;Borecki, Ingrid B;McCarthy, Mark I;Metspalu, Andres;Stefansson, Kari;Uitterlinden, André G;van Duijn, Cornelia M;Franke, Lude;Willer, Cristen J;Price, Alkes L.;Lettre, Guillaume;Loos, Ruth JF;Weedon, Michael N;Ingelsson, Erik;O’Connell, Jeffrey R;Abecasis, Goncalo R;Chasman, Daniel I;Goddard, Michael E;Visscher, Peter M;Hirschhorn, Joel N;Frayling, Timothy M
Issue Date: 2014
Description: Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explain one-fifth of heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ~2,000, ~3,700 and ~9,500 SNPs explained ~21%, ~24% and ~29% of phenotypic variance. Furthermore, all common variants together captured the majority (60%) of heritability. The 697 variants clustered in 423 loci enriched for genes, pathways, and tissue-types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/beta-catenin, and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.
URI: http://192.168.1.35:80/jspui/handle/Hannan/18131
Other Identifiers: Wood, A. R., T. Esko, J. Yang, S. Vedantam, T. H. Pers, S. Gustafsson, A. Y. Chu, et al. 2014. “Defining the role of common variation in the genomic and biological architecture of adult human height.” Nature genetics 46 (11): 1173-1186. doi:10.1038/ng.3097. http://dx.doi.org/10.1038/ng.3097.
1061-4036
http://nrs.harvard.edu/urn-3:HUL.InstRepos:16120873
Type Of Material: Journal Article
Appears in Collections:Harvard T.H. Chan School of Public Health

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