جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://192.168.1.35:80/jspui/handle/Hannan/20204
Title: Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Authors: Surendran, Praveen;Drenos, Fotios;Young, Robin;Warren, Helen;Cook, James P;Manning, Alisa K;Grarup, Niels;Sim, Xueling;Barnes, Daniel R;Witkowska, Kate;Staley, James R;Tragante, Vinicius;Tukiainen, Taru;Yaghootkar, Hanieh;Masca, Nicholas;Freitag, Daniel F;Ferreira, Teresa;Giannakopoulou, Olga;Tinker, Andrew;Harakalova, Magdalena;Mihailov, Evelin;Liu, Chunyu;Kraja, Aldi T;Fallgaard Nielsen, Sune;Rasheed, Asif;Samuel, Maria;Zhao, Wei;Bonnycastle, Lori L;Jackson, Anne U;Narisu, Narisu;Swift, Amy J;Southam, Lorraine;Marten, Jonathan;Huyghe, Jeroen R;Stančáková, Alena;Fava, Cristiano;Ohlsson, Therese;Matchan, Angela;Stirrups, Kathleen E;Bork-Jensen, Jette;Gjesing, Anette P;Kontto, Jukka;Perola, Markus;Shaw-Hawkins, Susan;Havulinna, Aki S;Zhang, He;Donnelly, Louise A;Groves, Christopher J;Rayner, N William;Neville, Matt J;Robertson, Neil R;Yiorkas, Andrianos M;Herzig, Karl-Heinz;Kajantie, Eero;Zhang, Weihua;Willems, Sara M;Lannfelt, Lars;Malerba, Giovanni;Soranzo, Nicole;Trabetti, Elisabetta;Verweij, Niek;Evangelou, Evangelos;Moayyeri, Alireza;Vergnaud, Anne-Claire;Nelson, Christopher P;Poveda, Alaitz;Varga, Tibor V;Caslake, Muriel;de Craen, Anton JM;Trompet, Stella;Luan, Jian’an;Scott, Robert A;Harris, Sarah E;Liewald, David CM;Marioni, Riccardo;Menni, Cristina;Farmaki, Aliki-Eleni;Hallmans, Göran;Renström, Frida;Huffman, Jennifer E;Hassinen, Maija;Burgess, Stephen;Vasan, Ramachandran S;Felix, Janine F;Uria-Nickelsen, Maria;Malarstig, Anders;Reily, Dermot F;Hoek, Maarten;Vogt, Thomas;Lin, Honghuang;Lieb, Wolfgang;Traylor, Matthew;Markus, Hugh F;Highland, Heather M;Justice, Anne E;Marouli, Eirini;Lindström, Jaana;Uusitupa, Matti;Komulainen, Pirjo;Lakka, Timo A;Rauramaa, Rainer;Polasek, Ozren;Rudan, Igor;Rolandsson, Olov;Franks, Paul W;Dedoussis, George;Spector, Timothy D;Jousilahti, Pekka;Männistö, Satu;Deary, Ian J;Starr, John M;Langenberg, Claudia;Wareham, Nick J;Brown, Morris J;Dominiczak, Anna F;Connell, John M;Jukema, J Wouter;Sattar, Naveed;Ford, Ian;Packard, Chris J;Esko, Tõnu;Mägi, Reedik;Metspalu, Andres;de Boer, Rudolf A;van der Meer, Peter;van der Harst, Pim;Gambaro, Giovanni;Ingelsson, Erik;Lind, Lars;de Bakker, Paul IW;Numans, Mattijs E;Brandslund, Ivan;Christensen, Cramer;Petersen, Eva RB;Korpi-Hyövälti, Eeva;Oksa, Heikki;Chambers, John C;Kooner, Jaspal S;Blakemore, Alexandra IF;Franks, Steve;Jarvelin, Marjo-Riitta;Husemoen, Lise L;Linneberg, Allan;Skaaby, Tea;Thuesen, Betina;Karpe, Fredrik;Tuomilehto, Jaakko;Doney, Alex SF;Morris, Andrew D;Palmer, Colin NA;Holmen, Oddgeir Lingaas;Hveem, Kristian;Willer, Cristen J;Tuomi, Tiinamaija;Groop, Leif;Käräjämäki, AnneMari;Palotie, Aarno;Ripatti, Samuli;Salomaa, Veikko;Alam, Dewan S;Shafi Majumder, Abdulla al;Di Angelantonio, Emanuele;Chowdhury, Rajiv;McCarthy, Mark I;Poulter, Neil;Stanton, Alice V;Sever, Peter;Amouyel, Philippe;Arveiler, Dominique;Blankenberg, Stefan;Ferrières, Jean;Kee, Frank;Kuulasmaa, Kari;Müller-Nurasyid, Martina;Veronesi, Giovanni;Virtamo, Jarmo;Deloukas, Panos;Elliott, Paul;Zeggini, Eleftheria;Kathiresan, Sekar;Melander, Olle;Kuusisto, Johanna;Laakso, Markku;Padmanabhan, Sandosh;Porteous, David;Hayward, Caroline;Scotland, Generation;Collins, Francis S;Mohlke, Karen L;Hansen, Torben;Pedersen, Oluf;Boehnke, Michael;Stringham, Heather M;Frossard, Philippe;Newton-Cheh, Christopher;Tobin, Martin D;Nordestgaard, Børge Grønne;Caulfield, Mark J;Mahajan, Anubha;Morris, Andrew P;Tomaszewski, Maciej;Samani, Nilesh J;Saleheen, Danish;Asselbergs, Folkert W;Lindgren, Cecilia M;Danesh, John;Wain, Louise V;Butterworth, Adam S;Howson, Joanna MM;Munroe, Patricia B
Issue Date: 2016
Description: High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to ~192,000 individuals, and used ~155,063 samples for independent replication. We identified 31 novel blood pressure or hypertension associated genetic regions in the general population, including three rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5mmHg/allele) than common variants. Multiple rare, nonsense and missense variant associations were found in A2ML1 and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.
URI: http://192.168.1.35:80/jspui/handle/Hannan/20204
Other Identifiers: Surendran, P., F. Drenos, R. Young, H. Warren, J. P. Cook, A. K. Manning, N. Grarup, et al. 2016. “Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.” Nature genetics 48 (10): 1151-1161. doi:10.1038/ng.3654. http://dx.doi.org/10.1038/ng.3654.
http://nrs.harvard.edu/urn-3:HUL.InstRepos:32072248
Type Of Material: Journal Article
Appears in Collections:Harvard T.H. Chan School of Public Health

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