جهت دسترسی به کاربرگه ی زیر، از این لینک استفاده کنید. http://192.168.1.35:80/jspui/handle/Hannan/3921
Title: Large-Scale Association Analysis Provides Insights into the Genetic Architecture and Pathophysiology of Type 2 Diabetes
Authors: Morris, Andrew P;Voight, Benjamin F;Teslovich, Tanya M;Ferreira, Teresa;Segré, Ayellet V;Steinthorsdottir, Valgerdur;Strawbridge, Rona J;Khan, Hassan;Grallert, Harald;Mahajan, Anubha;Prokopenko, Inga;Kang, Hyun Min;Dina, Christian;Esko, Tonu;Fraser, Ross M;Kanoni, Stavroula;Kumar, Ashish;Lagou, Vasiliki;Langenberg, Claudia;Luan, Jian’an;Lindgren, Cecilia M;Müller-Nurasyid, Martina;Pechlivanis, Sonali;Rayner, N William;Scott, Laura J;Wiltshire, Steven;Yengo, Loic;Kinnunen, Leena;Rossin, Elizabeth J;Raychaudhuri, Soumya;Johnson, Andrew D;Dimas, Antigone S;Loos, Ruth J F;Vedantam, Sailaja;Chen, Han;Florez, Jose Carlos;Fox, Caroline;Liu, Ching-Ti;Rybin, Denis;Couper, David J;Kao, Wen Hong L;Li, Man;Cornelis, Marilyn;Kraft, Peter Elias;Sun, Qi;van Dam, Rob M;Stringham, Heather M;Chines, Peter S;Fischer, Krista;Fontanillas, Pierre;Holmen, Oddgeir L;Hunt, Sarah E;Jackson, Anne U;Kong, Augustine;Lawrence, Robert;Meyer, Julia;Perry, John R B;Platou, Carl G P;Potter, Simon;Rehnberg, Emil;Robertson, Neil;Sivapalaratnam, Suthesh;Stančáková, Alena;Stirrups, Kathleen;Thorleifsson, Gudmar;Tikkanen, Emmi;Wood, Andrew R;Almgren, Peter;Atalay, Mustafa;Benediktsson, Rafn;Bonnycastle, Lori L;Burtt, Noël;Carey, Jason;Charpentier, Guillaume;Crenshaw, Andrew T;Doney, Alex S F;Dorkhan, Mozhgan;Edkins, Sarah;Emilsson, Valur;Eury, Elodie;Forsen, Tom;Gertow, Karl;Gigante, Bruna;Grant, George B;Groves, Christopher J;Guiducci, Candace;Herder, Christian;Hreidarsson, Astradur B;Hui, Jennie;James, Alan;Jonsson, Anna;Rathmann, Wolfgang;Klopp, Norman;Kravic, Jasmina;Krjutškov, Kaarel;Langford, Cordelia;Leander, Karin;Lindholm, Eero;Lobbens, Stéphane;Männistö, Satu;Mirza, Ghazala;Mühleisen, Thomas W;Musk, Bill;Parkin, Melissa Ann;Rallidis, Loukianos;Saramies, Jouko;Sennblad, Bengt;Shah, Sonia;Sigurðsson, Gunnar;Silveira, Angela;Steinbach, Gerald;Thorand, Barbara;Trakalo, Joseph;Veglia, Fabrizio;Wennauer, Roman;Winckler, Wendy;Zabaneh, Delilah;Campbell, Harry;van Duijn, Cornelia;Uitterlinden, Andre G;Hofman, Albert;Sijbrands, Eric;Abecasis, Goncalo R;Owen, Katharine R;Zeggini, Eleftheria;Trip, Mieke D;Forouhi, Nita G;Syvänen, Ann-Christine;Eriksson, Johan G;Peltonen, Leena;Nöthen, Markus M;Balkau, Beverley;Palmer, Colin N A;Lyssenko, Valeriya;Tuomi, Tiinamaija;Isomaa, Bo;Hunter, David J.;Qi, Lu;Shuldiner, Alan R;Roden, Michael;Barroso, Ines;Wilsgaard, Tom;Beilby, John;Hovingh, Kees;Price, Jackie F;Wilson, James F;Rauramaa, Rainer;Lakka, Timo A;Lind, Lars;Dedoussis, George;Njølstad, Inger;Pedersen, Nancy L;Khaw, Kay-Tee;Wareham, Nicholas J;Keinanen-Kiukaanniemi, Sirkka M;Saaristo, Timo E;Korpi-Hyövälti, Eeva;Saltevo, Juha;Laakso, Markku;Kuusisto, Johanna;Metspalu, Andres;Collins, Francis S;Mohlke, Karen L;Bergman, Richard N;Tuomilehto, Jaakko;Boehm, Bernhard O;Gieger, Christian;Hveem, Kristian;Cauchi, Stephane;Froguel, Philippe;Baldassarre, Damiano;Tremoli, Elena;Humphries, Steve E;Saleheen, Danish;Danesh, John;Ingelsson, Erik;Ripatti, Samuli;Salomaa, Veikko;Erbel, Raimund;Jöckel, Karl-Heinz;Moebus, Susanne;Peters, Annette;Illig, Thomas;de Faire, Ulf;Hamsten, Anders;Morris, Andrew D;Donnelly, Peter J;Frayling, Timothy M;Hattersley, Andrew T;Boerwinkle, Eric;Melander, Olle;Kathiresan, Sekar;Nilsson, Peter M;Deloukas, Panos;Thorsteinsdottir, Unnur;Groop, Leif C;Stefansson, Kari;Hu, Frank B.;Pankow, James S;Dupuis, Josée;Meigs, James Benjamin;Altshuler, David Matthew;Boehnke, Michael;McCarthy, Mark I
Issue Date: 2012
Publisher: Nature Publishing Group
Description: To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip involving 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two demonstrating sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of further common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signalling and cell cycle regulation, in diabetes pathogenesis.
URI: http://192.168.1.35:80/jspui/handle/Hannan/3921
Other Identifiers: Morris, Andrew P., Benjamin F. Voight, Tanya M. Teslovich, Teresa Ferreira, Ayellet V. Segré, Valgerdur Steinthorsdottir, Rona J. Strawbridge, et al. 2012. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics 44(9): 981-990.
1061-4036
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10589814
Type Of Material: Journal Article
Appears in Collections:Harvard Medical School

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